Trimethylaminuria: Genetic variants that cause a malodorous body odor | Genetic Lifehacks

FMO3 gene and trimethylaminuria (TMAU)

  • eggs
  • liver
  • kidney
  • peas
  • beans
  • peanuts
  • Brussels sprouts, broccoli, cabbage, cauliflower
  • lecithin
  • soy products
  • some mushrooms (ergothioneine)

Trimethylaminuria — strong body odor

Odor caused by TMAU

Is trimethylaminuria always genetic?

What else does the FMO3 enzyme do?

Genetic variants in the FMO3 gene linked to TMAU:

Common variants that decrease FMO3 enzyme function:

  • A/A: decreased FMO3 function[ref][ref][ref][ref] increased risk of hypertension, especially in smokers[ref]
  • A/G: somewhat decreased FMO3 function
  • G/G: typical FMO3 function
  • G/G: somewhat decreased FMO3 function[ref][ref][ref]
  • A/G: somewhat decreased FMO3 function
  • A/A: typical FMO3 function
  • T/T: somewhat decreased FMO3 function[ref][ref] (probably mild)
  • C/T: somewhat decreased FMO3 function
  • C/C: typical FMO3 function
  • A/A: decreased FMO3 function[ref] may add to trimethylaminuria combined with other FMO3 variants[ref][ref]
  • A/G: decreased FMO3 function
  • G/G: typical FMO3 function

More severe impact on FMO3 enzyme function (rare mutations):

  • A/A: trimethylaminuria possible in conjunction with a second mutation[ref]
  • A/G: decreased FMO3 function
  • G/G: typical
  • T/T: trimethylaminuria possible[ref]
  • C/T: decreased FMO3 function
  • C/C: typical
  • G/G: trimethylaminuria possible in conjunction with a second mutation[ref]
  • A/G: decreased FMO3 function
  • A/A: typical
  • T/T: decreased FMO3 function[ref]
  • G/T: decreased FMO3 function
  • G/G: typical FMO3 function
  • DD or -/-: decreased FMO3 function[ref]
  • DI or -/TG: decreased FMO3 function
  • II or TG/TG: typical FMO3 function

Lifehacks for trimethylaminuria:

Riboflavin (vitamin B2):

Probiotics:

Low choline diet:

Limiting fish in the diet:

Avoiding carnitine supplements:

Washing with a low pH soap:

Related Articles and Genes:

--

--

Science writer exploring the intersection of genetics, nutrition, and circadian rhythm: https://www.geneticlifehacks.com and https://www.longevitylifhehacks.me

Love podcasts or audiobooks? Learn on the go with our new app.

Get the Medium app

A button that says 'Download on the App Store', and if clicked it will lead you to the iOS App store
A button that says 'Get it on, Google Play', and if clicked it will lead you to the Google Play store
Debbie Moon

Debbie Moon

Science writer exploring the intersection of genetics, nutrition, and circadian rhythm: https://www.geneticlifehacks.com and https://www.longevitylifhehacks.me